Welcome to the Li+ Group
Department of Chemistry
University of New Hampshire
Department of Chemistry
University of New Hampshire
Back row: Prof. Jia Jia, Nicole Heath, Alec Espinola, Hayden, Nicholas Allen, Prof. Anyin Li
Front row: Shan Chen, Huishan Li, Taoqing Wang. Dr. Mengtian Li
Spring 2019
Front row: Shan Chen, Huishan Li, Taoqing Wang. Dr. Mengtian Li
Spring 2019
Mass Spectromentry
Electrospray is one of the most popular ionization methods for mass spectrometry (ESI-MS). Despite being routinely applied in the analysis of organic and biological molecules, it has many limitations that are usually addressed by additional efforts in sample preparation. We lack thorough understanding about these limitations.
The Li+ group has been focused on a few fundamental questions regarding ESI-MS. Where are the limits for the lowest flow rate and ionization current? What is, and how to generate the smallest possible initial charged droplet? What are the characteristics of an "ideal" ESI source and how can we build one? We believe these questions will lead us to expand our knowledge, and eventually to overcome the limitations one by one.
Research in my group has developed a few new approaches to conduct and study ESI-MS. Fundamentally new ESI approaches, such as sub-channel regime and femtoampere mode ESI, have been discovered. These developed methods provide superior performance for the analysis of hydrophilic compounds such as protein, glycan, and glycosylated compounds.
The Li+ group has been focused on a few fundamental questions regarding ESI-MS. Where are the limits for the lowest flow rate and ionization current? What is, and how to generate the smallest possible initial charged droplet? What are the characteristics of an "ideal" ESI source and how can we build one? We believe these questions will lead us to expand our knowledge, and eventually to overcome the limitations one by one.
Research in my group has developed a few new approaches to conduct and study ESI-MS. Fundamentally new ESI approaches, such as sub-channel regime and femtoampere mode ESI, have been discovered. These developed methods provide superior performance for the analysis of hydrophilic compounds such as protein, glycan, and glycosylated compounds.
Media Reports on the Types of Research We Do
